Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.

Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.

A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk factors. Detection of a PRS by environment (PRS x E) interact...

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Main Authors: W James Gauderman, Yubo Fu, Bryan Queme, Eric Kawaguchi, Yinqiao Wang, John Morrison, Hermann Brenner, Andrew Chan, Stephen B Gruber, Temitope Keku, Li Li, Victor Moreno, Andrew J Pellatt, Ulrike Peters, N Jewel Samadder, Stephanie L Schmit, Cornelia M Ulrich, Caroline Um, Anna Wu, Juan Pablo Lewinger, David A Drew, Huaiyu Mi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011543
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https://doi.org/10.1371/journal.pgen.1011543

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