New Insights into the Geometry and Topology of DNA Replication Intermediates

New Insights into the Geometry and Topology of DNA Replication Intermediates

The regulation of superhelical stress, mediated by the combined action of topoisomerases and fork rotation, is crucial for DNA replication. The conformational changes during DNA replication are still experimentally challenging, mainly due to the rapid kinetics of the replication process. Here, we pr...

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Bibliographic Details
Main Authors: Victor Martínez, Edith Ruiz-Díaz, Delia Cardozo, Cristian Cappo, Christian E. Schaerer, Jorge Cebrián, Dora B. Krimer, María José Fernández-Nestosa
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biology
Subjects:
DNA topology
DNA replication
superhelical stress
chirality
collision events
computational biology
Online Access:https://www.mdpi.com/2079-7737/14/5/478
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