A type-5 metabotropic glutamate receptor-perineuronal net axis shapes the function of cortical GABAergic interneurons in chronic pain

Abstract Parvalbumin-positive (PV+) interneurons (basket and chandelier cells) regulate the firing rate of pyramidal neurons in the cerebral cortex and play a key role in the generation of network oscillations in the cerebral cortex. A growing body of evidence suggest that cortical PV+ interneurons...

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Bibliographic Details
Main Authors: Giada Mascio, Ferdinando Nicoletti, Giuseppe Battaglia, Serena Notartomaso
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Anesthesia, Analgesia and Critical Care
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Online Access:https://doi.org/10.1186/s44158-025-00228-z
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