Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies

Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies

Aimed to elaborate new group of protein kinase inhibitors we conducted receptor-based screening (docking, QSAR modeling) and biochemical testing for derivatives of (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones. Methods and results. This study allowed identifying of new potential antican...

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Bibliographic Details
Main Authors: I. S. Nosulenko, O. Yu. Voskoboynik, O. M. Antypenko, G. G. Berest, S. I. Kovalenko
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2015-02-01
Series:Zaporožskij Medicinskij Žurnal
Subjects:
Quinazolines
Triazines
Casein Kinase II
Quantitative Structure-Activity Relationship
Molecular Docking Simulation
Online Access:http://zmj.zsmu.edu.ua/article/view/39873/36005
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http://zmj.zsmu.edu.ua/article/view/39873/36005

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