Synthesis, molecular docking, and anti-inflammatory evaluation of novel 4-(benzo[d][1,3]dioxol-5-yloxy)-N,N-2-yn-1-amine derivatives as potent cysteinyl leukotriene receptor (CysLT2) antagonists
Cysteinyl leukotrienes (CysLTs), derived from arachidonic acid, play a crucial role in regulating inflammation. We synthesized a novel series of CysLT2 antagonists containing the benzo[d][1,3]dioxole moiety using a synthetic strategy based on the Mannich reaction, resulting in the formation of 4-(be...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2025-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/143171/download/pdf/ |
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