A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction

A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction

Resume. Methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by isoproterenol (20 |jg/kg/ min, i.v.). Endothelial dysfunction was induced, causing hyperhomocysteinemia in rats (methionine 3 g/kg intragastrically 1 time per day for 7 days). The...

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Bibliographic Details
Main Authors: V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2019-02-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
α, ω-диарилметильные производные бис-(ω-аминоалкил)аминов
алм-802
триметазидин
субэндокардиальная ишемия
эндотелиальная дисфункция
р-fox ингибиторы
α, ω-diarylmethyl derivatives of bis-(ω-aminoalkyl) amines
alm-802
trimetazidine
subendocardial ischemia
endothelial dysfunction
p-fox inhibitors
Online Access:https://www.pharmacokinetica.ru/jour/article/view/89
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