Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus
Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation. Considering that migration capacity is important for the exertion of BMSCs function...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/169082 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552192728367104 |
|---|---|
| author | Linyu Geng Xia Li Xuebing Feng Jiyun Zhang Dandan Wang Jinyun Chen Rui Liu Haifeng Chen Lingyun Sun |
| author_facet | Linyu Geng Xia Li Xuebing Feng Jiyun Zhang Dandan Wang Jinyun Chen Rui Liu Haifeng Chen Lingyun Sun |
| author_sort | Linyu Geng |
| collection | DOAJ |
| description | Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation. Considering that migration capacity is important for the exertion of BMSCs functions, the defects in migration might contribute to BMSCs dysfunction in SLE patients. In this study, we showed that the migration capacity of SLE BMSCs was remarkably impaired in comparison with those of healthy controls. Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited the migration capacity and in vivo homing capacity of SLE BMSCs via a specific TNF receptor I (TNFRI) manner, in which decreased HGF mRNA production caused by the activation of I kappa B kinase beta (IKK-β) pathway is partially involved. To our knowledge, this is the first report to discuss the possible mechanisms for impaired migration of BMSCs in SLE patients. Our results suggest that inhibition of TNF-α pathway might be helpful for accelerating BMSCs migration to the inflammatory microenvironment in SLE patients, thereby having a potential role in SLE treatment. |
| format | Article |
| id | doaj-art-f156ce000e2045d980eb3c7a75bc0714 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f156ce000e2045d980eb3c7a75bc07142025-02-03T05:59:29ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/169082169082Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus ErythematosusLinyu Geng0Xia Li1Xuebing Feng2Jiyun Zhang3Dandan Wang4Jinyun Chen5Rui Liu6Haifeng Chen7Lingyun Sun8Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, ChinaPrevious studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation. Considering that migration capacity is important for the exertion of BMSCs functions, the defects in migration might contribute to BMSCs dysfunction in SLE patients. In this study, we showed that the migration capacity of SLE BMSCs was remarkably impaired in comparison with those of healthy controls. Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited the migration capacity and in vivo homing capacity of SLE BMSCs via a specific TNF receptor I (TNFRI) manner, in which decreased HGF mRNA production caused by the activation of I kappa B kinase beta (IKK-β) pathway is partially involved. To our knowledge, this is the first report to discuss the possible mechanisms for impaired migration of BMSCs in SLE patients. Our results suggest that inhibition of TNF-α pathway might be helpful for accelerating BMSCs migration to the inflammatory microenvironment in SLE patients, thereby having a potential role in SLE treatment.http://dx.doi.org/10.1155/2014/169082 |
| spellingShingle | Linyu Geng Xia Li Xuebing Feng Jiyun Zhang Dandan Wang Jinyun Chen Rui Liu Haifeng Chen Lingyun Sun Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus |
| title_full | Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus |
| title_fullStr | Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus |
| title_full_unstemmed | Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus |
| title_short | Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus |
| title_sort | association of tnf α with impaired migration capacity of mesenchymal stem cells in patients with systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2014/169082 |
| work_keys_str_mv | AT linyugeng associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT xiali associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT xuebingfeng associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT jiyunzhang associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT dandanwang associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT jinyunchen associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT ruiliu associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT haifengchen associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus AT lingyunsun associationoftnfawithimpairedmigrationcapacityofmesenchymalstemcellsinpatientswithsystemiclupuserythematosus |