MORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer

MORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer

Abstract Background Although immunotherapy has achieved great progress in advanced triple-negative breast cancer (TNBC), there are still numerous patients who do not benefit from immunotherapy. Therefore, identification of the key molecule that induces immune escape and clarification of its specific...

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Main Authors: Xin-Yi Sui, Shuo-Wen Cao, Xiao-Qing Song, Xi-Yu Liu, Chao Chen, Qingya Yan, Zhi-Qing Wang, Wen-Juan Zhang, Lin-Xiaoxi Ma, Xi Jin, Ding Ma, Yi Xiao, Song-Yang Wu, Ying Xu, Zhi-Ming Shao, Lei Fan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biomarker Research
Subjects:
Triple-negative breast cancer
Mortality factor 4 like 2
Anti-PD1
Tumor microenvironment
Histone 4 lysine 12 acetylation
Combination therapy
Online Access:https://doi.org/10.1186/s40364-024-00719-1
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https://doi.org/10.1186/s40364-024-00719-1

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