Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we util...

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Main Authors: Brian Spencer, Robert A Marr, Ryan Gindi, Rewati Potkar, Sarah Michael, Anthony Adame, Edward Rockenstein, Inder M Verma, Eliezer Masliah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016575&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016575&type=printable

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