Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway

Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway

Abstract The interaction of Helicobacter pylori with cancer-associated fibroblasts (CAFs) to promote cholangiocarcinoma (CCA) genesis is unclear. We aimed to demonstrate the effect and mechanism of H. pylori on function of CAFs in vitro as well as the role of melatonin as an anti-fibrotic agent capa...

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Main Authors: Sirinapha Klungsaeng, Nuttanan Hongsrichan, Apisit Chaidee, Kitti Intuyod, Porntip Pinlaor, Sittiruk Roytrakul, Kulthida Vaeteewoottacharn, Sawanya Charoenlappanit, Rungtiwa Dangtakot, Narumon Mahaamnad, Somchai Pinlaor
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
H. pylori cagA+
Bile duct cancer
Cancer-associated fibroblasts
FAK pathway
PI3K and β-catenin
Online Access:https://doi.org/10.1038/s41598-025-99980-z
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https://doi.org/10.1038/s41598-025-99980-z

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