Isoaspartate-containing galanin in rat hypothalamus

Abstract The isoaspartate residue is a spontaneous, time-dependent post-translational modification (PTM) of proteins and peptides, associated with in vivo protein aggregation and changes in molecule lifetime. While this is considered a slow modification impacting long lived proteins, surprisingly, w...

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Bibliographic Details
Main Authors: Samuel Okyem, David H. Mast, Elena V. Romanova, Stanislav S. Rubakhin, Jonathan V. Sweedler
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01475-5
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