Inhibition of CDH11 Activates cGAS‐STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma

Inhibition of CDH11 Activates cGAS‐STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma

Abstract Salivary adenoid cystic carcinoma (SACC) is an intractable malignant tumor originates in the secretory glands and frequently metastasizes to the lungs. Hybrid epithelial‐mesenchymal transition (EMT) cells within the tumors are correlated with augmented proliferative capacity and facilitatio...

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Main Authors: Rui‐Feng Li, Shuo Liu, Qian Gao, Min Fu, Xin‐Yi Sun, Mian Xiao, Xi‐Yuan Ge, Xin Peng
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
adenoid cystic carcinoma
celecoxib
hybrid epithelial‐mesenchymal transforming cells
spatial transcriptome sequencing
single‐cell transcriptome sequencing
targeted therapy
Online Access:https://doi.org/10.1002/advs.202408751
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https://doi.org/10.1002/advs.202408751

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