Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence

Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence

Introduction: Rituximab is a first-line treatment for membranous nephropathy. Nephrotic syndrome limits rituximab exposure due to urinary drug loss. Rituximab underdosing (serum level <2 μg/ml at month-3) is a risk factor for treatment failure. We developed a machine learning algorithm to predict...

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Main Authors: Alexandre Destere, Maxime Teisseyre, Diane Merino, Marion Cremoni, Alexandre O Gérard, Thomas Crepin, Noémie Jourde-Chiche, Daisy Graça, Kévin Zorzi, Céline Fernandez, Vesna Brglez, Sylvia Benzaken, Vincent L.M. Esnault, Sylvain Benito, Milou-Daniel Drici, Barbara Seitz-Polski
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Kidney International Reports
Subjects:
artificial intelligence
immunomonitoring
machine learning
nephrotic syndrome
primary membranous nephropathy
rituximab
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024923015632
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