Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking
Plk4 plays a crucial role in controlling the duplication of centrioles and initiating the creation of centrosomes. Disruption of Plk4 leads to aneuploidy and chromosome instability, contributing to aggressive cancers, as well as microcephaly and fatal ciliopathies in children. To effectively treat c...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2025-06-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/149240/download/pdf/ |
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