An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses.

An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses.

Mycobacterium tuberculosis (M.tb) infection causes marked tissue inflammation leading to lung destruction and morbidity. The inflammatory extracellular microenvironment is acidic, however the effect of this acidosis on the immune response to M.tb is unknown. Using RNA-seq we show that acidosis produ...

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Main Authors: Ashley M Whittington, Frances S Turner, Friedrich Baark, Sam Templeman, Daniela E Kirwan, Candice Roufosse, Nitya Krishnan, Brian D Robertson, Deborah L W Chong, Joanna C Porter, Robert H Gilman, Jon S Friedland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011495&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011495&type=printable

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