Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ

Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ

Abstract Hepatic ischemia‒reperfusion injury (HIRI) is a common pathological phenomenon after hepatectomy and liver transplantation. Here, we aim to explore the role of Axin formation inhibitor 1 (Axin1) in HIRI. In this work, we find that the expression of Axin1 is upregulated after HIRI. Cellular...

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Main Authors: Baolin Qian, Bing Yin, Hongjun Yu, Chaoqun Wang, Shounan Lu, Shanjia Ke, Zihao Li, Xinglong Li, Yongliang Hua, Zhongyu Li, Yongzhi Zhou, Zhanzhi Meng, Yao Fu, Wei Tang, Yong Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56967-8
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https://doi.org/10.1038/s41467-025-56967-8

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