Are diurnal variations in glymphatic clearance driven by circadian regulation of Aquaporin-4 expression?

Are diurnal variations in glymphatic clearance driven by circadian regulation of Aquaporin-4 expression?

Abstract Aquaporin-4 (AQP4) is a key astrocytic water channel protein predominantly localized to perivascular endfeet, where it is believed to play a crucial role in brain fluid homeostasis and glymphatic waste clearance. Previous studies have suggested that the perivascular expression of AQP4 is re...

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Bibliographic Details
Main Authors: Mina Martine Frey, Negar Zohoorian, Nadia Skauli, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Aquaporins
Astrocyte polarity
Glymphatics
Glia
Perivascular endfeet
Circadian rhythm
Online Access:https://doi.org/10.1186/s12987-025-00676-3
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https://doi.org/10.1186/s12987-025-00676-3

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