MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3/NADH-CoQ axis for OA treatment

MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3/NADH-CoQ axis for OA treatment

Abstract Background Osteoarthritis (OA) is a prevalent degenerative joint disease and current therapies are insufficient to halt its progression. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) offer promising therapeutic potential for OA treatment, and their efficacy can be enhance...

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Bibliographic Details
Main Authors: Jingdi Zhan, Jing Zou, Qiming Pang, Zhuolin Chen, Junyan Liu, Senrui Liu, Chengcheng Du, Jiacheng Liu, Weikang Zhao, Lili Dong, Wei Huang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
MSCs-derived extracellular vesicles
Engineered
Macrophages
Mitochondria metabolism
mt-ND3
Osteoarthritis
Online Access:https://doi.org/10.1186/s12951-025-03216-1
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https://doi.org/10.1186/s12951-025-03216-1

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