Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, posing serious threats to global health. Effective broad-spectrum antiviral drugs for the treatment of COVID-19 are not sufficiently available. In the present study, we investiga...

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Bibliographic Details
Main Authors: Binli Mao, Vu Thuy Khanh Le-Trilling, Haihuan Tang, Jie Hu, Mona S. Schmitz, Kimberly Barbet, Dan Xu, Zhen Wei, Beinu Guo, Denise Mennerich, Chun Yao, Jinxin Liu, Zhenghan Li, Yushun Wan, Xiaoyong Zhang, Kai Wang, Ni Tang, Zebo Yu, Mirko Trilling, Yong Lin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Virus Research
Subjects:
Diphyllin
SARS-CoV-2
Endocytosis
Cathepsin L
Cell surface entry
Furin
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170224001783
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