A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B.

Chronic hepatitis B virus (HBV) infection is strongly associated with increased risk of liver cancer and cirrhosis. While existing treatments effectively inhibit the HBV life cycle, viral rebound frequently occurs following treatment interruption. Consequently, functional cure rates of chronic HBV i...

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Bibliographic Details
Main Authors: Sarafa A Iyaniwura, Tyler Cassidy, Ruy M Ribeiro, Alan S Perelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012322
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