Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization

Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization

IntroductionPeriodontitis has been identified as a potential risk factor for cognitive impairment associated with immune dysregulation. T helper 17 (Th17) cell-associated immune responses are involved in both diseases, while signal transducer and activator of transcription 3 (Stat3) is kown to be cr...

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Bibliographic Details
Main Authors: Yining Zhou, Xinyi Xie, Huiwen Chen, Lina Xu, Che Qiu, Hui Shen, Wei Zhou, Zhongchen Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
periodontitis
cognitive impairment
neuroinflammation
Th17 cells
Stat3
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590665/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590665/full

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