Assessing the carcinogenic potential and molecular mechanisms of arecoline in human lungs: from in silico methods to in vitro validation

Objective: Despite the globally recognized carcinogenic potential of arecoline, the primary active compound in areca nut, the molecular mechanisms underlying its role in lung adenocarcinoma (LUAD) have yet to be fully understood. This study aims to bridge this gap by integrating network toxicology,...

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Bibliographic Details
Main Author: Wenwen Wang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325004440
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