Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S)

Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S)

Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. AMD development is associated with inflammation, oxidative stress, and a progressive proteostasis imbalance, in whose regulation, c-Jun N-terminal kinases (JNKs) play a crucial role. JNK inhibiti...

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Bibliographic Details
Main Authors: Natalia A. Muraleva, Dmitry I. Tikhonov, Anna A. Zhdankina, Mark B. Plotnikov, Andrei I. Khlebnikov, Sergey V. Logvinov, Nataliya G. Kolosova
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
age
retina
age-related macular degeneration
JNK signaling
synapses
JNK inhibitor
Online Access:https://www.mdpi.com/2073-4409/14/12/896
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