Case Report: Influence of BRCA1 germline mutation on treatment-related morbidity of a non-seminomatous germ cell tumor patient

Case Report: Influence of BRCA1 germline mutation on treatment-related morbidity of a non-seminomatous germ cell tumor patient

We present the case of a 47-year-old male with advanced non-seminomatous germ cell tumor, who was found to carry a heterozygous pathogenic BRCA1 germline variant following molecular testing due to a positive family history. While tumor analysis did not confirm loss of heterozygosity, evidence sugges...

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Bibliographic Details
Main Authors: Bruno Griesler, Susann Schulze, Thomas Kegel, Christine Dierks, Pablo Villavicencio-Lorini, Markus Eszlinger, Haifa Kathrin Al-Ali, Nadja Jaekel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
hematotoxicity
chemotherapy - oncology
neutropenia and fever
case report
BRCA1 mutation
GCT = germ cell tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1579574/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1579574/full

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