Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration

Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration

CTCF is a key factor in three-dimensional chromatin folding and transcriptional control that was found to affect cancer cell migration by a mechanism that is still poorly understood. To identify this mechanism, we used mouse melanoma cells with a partial loss of function (pLoF) of CTCF. We found tha...

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Bibliographic Details
Main Authors: Lukasz Stanislaw Kaczmarczyk, Dagmawit Babele, Nehora Levi, Gowthaman Gunasekaran, Mali Salmon-Divon, Gabi Gerlitz
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Cell Biology
Subjects:
Cell migration
Cholesterol
Fatostatin
Chromatin
Migrasome
SREBP
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000712
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