Evaluation of kidney injury and metabolomic analysis in adulthood in a non-obese hyperglycemic female mouse model after birth with low birthweight

Evaluation of kidney injury and metabolomic analysis in adulthood in a non-obese hyperglycemic female mouse model after birth with low birthweight

Abstract Background Low birthweight infants have high risk of developing chronic kidney disease (CKD) in later in life, however, the pathogenesis of this disease remains unclear. This study aimed to investigate the underlying mechanism using a low birthweight-non-obese hyperglycemic adulthood mouse...

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Main Authors: Shoichi Shimizu, Nobuhiko Nagano, Daichi Katayama, Kengo Matsuda, Wataru Tokunaga, Kimitaka Nakazaki, Ryoji Aoki, Kazumasa Fuwa, Ichiro Morioka
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Chronic kidney disease (CKD)
Non-obese-hyperglycemia
Uterine artery ischemia
Metabolomic analysis
Developmental origins of health and disease (DOHaD)
Small-for-gestational-age (SGA)
Online Access:https://doi.org/10.1186/s12882-025-04290-1
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https://doi.org/10.1186/s12882-025-04290-1

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