Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study

Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study

<b>Background/Objectives:</b> Glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) is a debilitating condition resulting from impaired bone metabolism and vascular disruption due to prolonged glucocorticoid use. This study aimed to explore the therapeutic potential of salvige...

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Bibliographic Details
Main Authors: Zhengjie Zhu, Yujian Zhong, Ruyuan He, Changheng Zhong, Junwen Chen, Hao Peng
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
network pharmacology
salvigenin
osteonecrosis of femoral head
osteoblast apoptosis
oxidative stress
Online Access:https://www.mdpi.com/2227-9059/13/3/614
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