Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus

Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus

Abstract Background Hyaluronic acid (HA) is extensively employed in various fields such as medicine, cosmetics, food, etc. The molecular weight (MW) of HA is crucial for its biological functions. Streptococcus zooepidemicus, a prominent HA industrial producer, naturally synthetizes HA with high MW....

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Main Authors: Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Microbial Cell Factories
Subjects:
Streptococcus zooepidemicus
Hyaluronic acid
Precursor supply balance
Sucrose-induced expression system
Molecular weight regulation
hasE gene
Online Access:https://doi.org/10.1186/s12934-024-02624-6
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https://doi.org/10.1186/s12934-024-02624-6

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