Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists.

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists.

Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule, major histocompatibility complex class I-rela...

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Main Authors: Melissa D Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L Raphela, Gwendolyn M Swarbrick, Paul S Soma, Mandisa Zuma, Digby F Warner, Deborah A Lewinsohn, Carolina Mehaffy, Erin J Adams, William Hildebrand, Karen M Dobos, Valerie Mizrahi, David M Lewinsohn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012632
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https://doi.org/10.1371/journal.ppat.1012632

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