Novel Antimicrobial and Antitumor Agents Bearing Pyridine-1,2,4-triazole-3-thione-hydrazone Scaffold: Synthesis, Biological Evaluation, and Molecular Docking Investigation

Novel Antimicrobial and Antitumor Agents Bearing Pyridine-1,2,4-triazole-3-thione-hydrazone Scaffold: Synthesis, Biological Evaluation, and Molecular Docking Investigation

A series of target 4-substituted-5-(2-(pyridine-2-ylamino)ethyl)-2,4-dihydro-3<i>H</i>-1,2,4-triazole-3-thiones and their chloro analogs <b>7</b>–<b>21</b> were synthesized in a reaction of the selected aldehydes with the corresponding 4-amino-1,2,4-triazole-3-thi...

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Main Authors: Aida Šermukšnytė, Maryna Stasevych, Olena Komarovska-Porokhnyavets, Viktor Zvarych, Eglė Jakubauskienė, Kristina Kantminienė, Ingrida Tumosienė
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
pyrrolidin-2-one
hydrazone
triple-negative breast cancer
glioblastoma
cell viability
MTT assay
Online Access:https://www.mdpi.com/2218-273X/14/12/1529
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