<i>Phaseolus acutifolius</i> Recombinant Lectin Exerts Differential Proapoptotic Activity on EGFR<sup>+</sup> and EGFR<sup>−</sup> Colon Cancer Cells and Provokes T Cell-Assisted Antitumor Responses in Mice

<i>Phaseolus acutifolius</i> Recombinant Lectin Exerts Differential Proapoptotic Activity on EGFR<sup>+</sup> and EGFR<sup>−</sup> Colon Cancer Cells and Provokes T Cell-Assisted Antitumor Responses in Mice

<b>Background:</b> <i>r</i>TBL-1, a recombinant lectin from <i>Phaseolus acutifolius</i>, exhibit proapoptotic activity on colon cancer cells and inhibitory properties on colon tumorigenesis in vivo. Apoptosis has been associated with a phospho-EGFR/phospho-p38/ph...

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Bibliographic Details
Main Authors: Francisco Luján-Méndez, Patricia García-López, Laura C. Berumen, Guadalupe García-Alcocer, Roberto Ferriz-Martínez, Anette Ramírez-Carrera, Jaqueline González-Barrón, Teresa García-Gasca
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
colorectal cancer
colon cancer
recombinant lectin
<i>Phaseolus acutifolius</i>
biopharmaceutical candidate
T cells
Online Access:https://www.mdpi.com/1424-8247/18/2/213
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