Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML and loss of one p53 gene: Report of two cases and literature review

Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML and loss of one p53 gene: Report of two cases and literature review

Introduction. The isochromosome of the long arm of derivative chromosome 17, that originates from the translocation t(15;17) [ider(17)(q10)t(15;17), or ider(17q)] in acute promyelocytic leukemia (APL), is a rare chromosome aberration associated with a poor prognosis. Case report. We report the clini...

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Main Authors: Đorđević Vesna, Denčić-Fekete Marija, Jovanović Jelica, Virijević Marijana, Kraguljac-Kurtović Nada, Jaković Ljubomir, Bogdanović Andrija
Format: Article
Language:English
Published: Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade 2019-01-01
Series:Vojnosanitetski Pregled
Subjects:
leukemia, myeloid
chromosome abberations
in situ hybridization, fluorescence
translocation, genetic
genes, p53
mortality
retinoic acid receptor alpha
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700174D.pdf
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