GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice

GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice

Abstract Dopamine (DA) transmission from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) is strongly associated with depression in Parkinson’s disease (PD). Decreased DA levels due to alpha-synuclein (α-syn) aggregation have been underappreciated in relation to depression in PD. This...

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Bibliographic Details
Main Authors: Jing Chen, Zhi Ling, Maokang Lv, Shengzhe Chen, Wei Xu, Lin Shao, Zifan Ma, Chuanxu Wang, Yuanjian Song, Chuanxi Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Parkinson’s disease
Alpha-synuclein
Depression
Glial cell line-derived neurotrophic factor
Dopamine D2-type receptors
Online Access:https://doi.org/10.1038/s41598-025-16556-7
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https://doi.org/10.1038/s41598-025-16556-7

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