Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient
Talc is commonly used as an excipient for drug formulations. The general expectation is that the excipient should have only minimal interactions with the carrying drug. In this study, the adsorption of atenolol (AT), a β-blocker, on talc, a clay mineral of pH-dependent surface charge, was evaluated...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-04-01
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| Series: | Adsorption Science & Technology |
| Online Access: | https://doi.org/10.1260/0263-6174.33.4.379 |
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| author | Zhaohui Li Nicole M. Fitzgerald Guocheng Lv Wei-Teh Jiang Limei Wu |
| author_facet | Zhaohui Li Nicole M. Fitzgerald Guocheng Lv Wei-Teh Jiang Limei Wu |
| author_sort | Zhaohui Li |
| collection | DOAJ |
| description | Talc is commonly used as an excipient for drug formulations. The general expectation is that the excipient should have only minimal interactions with the carrying drug. In this study, the adsorption of atenolol (AT), a β-blocker, on talc, a clay mineral of pH-dependent surface charge, was evaluated under different physicochemical conditions such as the initial AT concentration, equilibrium time, solution pH, ionic strength and temperature. Our experiments showed that talc had an AT adsorption capacity of 11 mmol/kg. In addition, adsorption of AT on talc was instantaneous, which suggests that the adsorption sites were located on the external surfaces or edges. Factors such as solution pH, ionic strength and temperature all had minimal influence on AT adsorption, although the adsorption process was exothermic and the free energy of adsorption was negative, indicating weak physical adsorption. The Fourier transform infrared results showed blue shifts of the bands corresponding to δ(C–OH) at 1410 and 1043 cm −1 , indicating hydrogen bonding for the uptake of AT on talc surfaces or edges. |
| format | Article |
| id | doaj-art-efebd352844d4210b1606bdeaac4ad3a |
| institution | Kabale University |
| issn | 0263-6174 2048-4038 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Adsorption Science & Technology |
| spelling | doaj-art-efebd352844d4210b1606bdeaac4ad3a2025-01-03T00:11:56ZengSAGE PublishingAdsorption Science & Technology0263-61742048-40382015-04-013310.1260/0263-6174.33.4.379Adsorption of Atenolol on Talc: An Indication of Drug Interference with an ExcipientZhaohui Li0Nicole M. Fitzgerald1Guocheng Lv2Wei-Teh Jiang3Limei Wu4 Department of Earth Science, National Cheng Kung University, 1 University Road, Tainan, Taiwan 70101 Geosciences Department, University of Wisconsin-Parkside, Kenosha, WI 53144, USA Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 29 Xueyuan Road, Beijing, China 100083 Department of Earth Science, National Cheng Kung University, 1 University Road, Tainan, Taiwan 70101 Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 29 Xueyuan Road, Beijing, China 100083Talc is commonly used as an excipient for drug formulations. The general expectation is that the excipient should have only minimal interactions with the carrying drug. In this study, the adsorption of atenolol (AT), a β-blocker, on talc, a clay mineral of pH-dependent surface charge, was evaluated under different physicochemical conditions such as the initial AT concentration, equilibrium time, solution pH, ionic strength and temperature. Our experiments showed that talc had an AT adsorption capacity of 11 mmol/kg. In addition, adsorption of AT on talc was instantaneous, which suggests that the adsorption sites were located on the external surfaces or edges. Factors such as solution pH, ionic strength and temperature all had minimal influence on AT adsorption, although the adsorption process was exothermic and the free energy of adsorption was negative, indicating weak physical adsorption. The Fourier transform infrared results showed blue shifts of the bands corresponding to δ(C–OH) at 1410 and 1043 cm −1 , indicating hydrogen bonding for the uptake of AT on talc surfaces or edges.https://doi.org/10.1260/0263-6174.33.4.379 |
| spellingShingle | Zhaohui Li Nicole M. Fitzgerald Guocheng Lv Wei-Teh Jiang Limei Wu Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient Adsorption Science & Technology |
| title | Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient |
| title_full | Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient |
| title_fullStr | Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient |
| title_full_unstemmed | Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient |
| title_short | Adsorption of Atenolol on Talc: An Indication of Drug Interference with an Excipient |
| title_sort | adsorption of atenolol on talc an indication of drug interference with an excipient |
| url | https://doi.org/10.1260/0263-6174.33.4.379 |
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