Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation

Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation

The inhibition of methionine adenosyltransferase 2A (MAT2A) in cancers harboring deletions of the methylthioadenosine phosphorylase (MTAP) gene induces synthetic lethality, making it a highly compelling strategy in the pursuit of precision anticancer therapeutics. In this study, structure-based comp...

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Bibliographic Details
Main Authors: Chunchun Qi, Xinghui Yu, Siyu Zuo, Pinsheng Han, Ruonan An, Yamin Zhang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
methionine adenosyltransferase 2A (MAT2A)
synthetic lethality
virtual screening
Online Access:https://www.mdpi.com/1420-3049/30/10/2134
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