scCTS: identifying the cell type-specific marker genes from population-level single-cell RNA-seq

scCTS: identifying the cell type-specific marker genes from population-level single-cell RNA-seq

Abstract Single-cell RNA-sequencing (scRNA-seq) provides gene expression profiles of individual cells from complex samples, facilitating the detection of cell type-specific marker genes. In scRNA-seq experiments with multiple donors, the population level variation brings an extra layer of complexity...

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Bibliographic Details
Main Authors: Luxiao Chen, Zhenxing Guo, Tao Deng, Hao Wu
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Genome Biology
Subjects:
Single-cell RNA-seq
Cell type-specific genes
Differential expression
Hierarchical model
Online Access:https://doi.org/10.1186/s13059-024-03410-8
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https://doi.org/10.1186/s13059-024-03410-8

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