SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, especially in bats—natural reservoirs of sarbecoviruses...

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Bibliographic Details
Main Authors: Risako Gen, Amin Addetia, Daniel Asarnow, Young-Jun Park, Joel Quispe, Matthew C. Chan, Jack T. Brown, Jimin Lee, Melody G. Campbell, Christopher P. Lapointe, David Veesler
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500467X
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http://www.sciencedirect.com/science/article/pii/S221112472500467X

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