Clinical Features and PTCH1 Expression in Gorlin–Goltz Syndrome: A Case Report

Clinical Features and PTCH1 Expression in Gorlin–Goltz Syndrome: A Case Report

<b>Background and Clinical Significance:</b> Basal cell nevoid carcinoma syndrome, or Gorlin–Goltz Syndrome (GGS), is a genetic disease caused by germline mutations in genes involved in the Sonic HedgeHog (SHH) signaling pathway, mainly in the PTCH1 gene. PTCH1 is a receptor for SHH, and...

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Main Authors: Gabriela González-López, Samuel Mendoza-Álvarez, Claudia Patricia Mejia-Velazquez, Carla Monserrat Ramírez-Martínez, Alejandro Alonso-Moctezuma, Luis Fernando Jacinto-Alemán
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Reports
Subjects:
Gorlin–Goltz syndrome
odontogenic keratocysts
PTCH1
RT-PCR
basal cell carcinoma
Online Access:https://www.mdpi.com/2571-841X/8/1/34
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