Non-immunogenic staphylokinase — a thrombolytic agent in the treatment of massive pulmonary embolism: results of the FORPE clinical trial

Non-immunogenic staphylokinase — a thrombolytic agent in the treatment of massive pulmonary embolism: results of the FORPE clinical trial

Aim. To assess the safety and efficacy of a single intravenous bolus of non-immunogenic staphylokinase compared with alteplase in patients with massive pulmonary embolism and hemodynamic instability. Non-immunogenic staphylokinase is a modified recombinant staphylokinase with low immunogenicity, hig...

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Main Authors: A. I. Kirienko, S. G. Leontyev, E. B. Yarovaya, S. I. Konstantinov, B. B. Orlov, Imad Meray, D. V. Duplyakov, V. E. Oleynikov, E. Yu. Vasilyeva, E. A. Ponomarev, S. A. Pribylov, A. G. Komarova, V. V. Bobkov, R. M. Rabinovich, G. V. Klein, Z. S. Shogenov, Yu. V. Karabach, V. N. Zolkin, V. V. Kulabukhov, V. V. Kashtalap, K. A. Linev, G. I. Stryabkova, N. V. Yasnopolskaya, V. Yu. Tolmacheva, Zh. Yu. Chefranova, Yu. A. Lykov, E. S. Panina, N. V. Solovieva, E. V. Rybin, N. V. Furman, E. V. Kulibaba, V. V. Makukhin, A. G. Koledinsky, I. S. Mullova, N. A. Cherepanova, T. V. Pavlova, P. P. Savvinova, I. A. Libov, A. S. Igoshin, I. Yu. Bogomazov, T. B. Pecherina, L. O. Lyudnev, P. N. Vlasov, I. V. Avdeeva, D. B. Maksimov, E. V. Komissarova, V. S. Ivanov, N. L. Vyazova, E. V. Vyshlov, D. S. Kurtasov, V. A. Kutsenko, O. E. Ivlev, A. G. Soplenkova, S. N. Tereshchenko, I. S. Yavelov, R. M. Shakhnovich, A. D. Erlikh, O. B. Talibov, A. M. Semenov, M. P. Semenov, S. V. Ivanov, Yu. A. Romashova, V. V. Beregovykh, A. I. Archakov, S. S. Markin
Format: Article
Language:Russian
Published: «FIRMA «SILICEA» LLC 2024-12-01
Series:Российский кардиологический журнал
Subjects:
non-immunogenic staphylokinase
massive pulmonary embolism
thrombolytic therapy
randomized clinical trial
Online Access:https://russjcardiol.elpub.ru/jour/article/view/6157
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