Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway

Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway

Exercise ameliorates pulmonary hypertension (PH) progression. However, the underlying mechanisms are largely unclear. Musclin is an exercise-responsive myokine that exerts protective effects on cardiovascular diseases. The current study aims to explore the role of musclin in the development of PH. A...

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Bibliographic Details
Main Authors: Sun Xiongshan, Wang Jia, Xiao Yi, Li De, Wang Qiang, Guo Wei, Yang Yongjian
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
musclin
PASMC
PH
mTORC1
NPR3
glycolysis
oxidative stress
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024214
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https://www.sciengine.com/doi/10.3724/abbs.2024214

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