Pathogenic morphological signatures of perturbations in mitochondrial-related genes revealed by pooled imaging assay
Abstract Mutations in mitochondrial-related genes underlie numerous neurodegenerative diseases, yet the significance of most variants remains uncertain concerning disease phenotypes. Several thousand genes have been shown to regulate mitochondria in eukaryotic cells, but which of these genes are nec...
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| Main Authors: | Colin Kremitzki, Jason Waligorski, Graham Bachman, Lina Mohammed Ali, John Bramley, Maria Vakaki, Vinay Chandrasekaran, Purva Patel, Dhruv Mathur, Paul Hime, Robi Mitra, Jeff Milbrandt, William Buchser |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | npj Imaging |
| Online Access: | https://doi.org/10.1038/s44303-025-00097-9 |
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