Pathogenic morphological signatures of perturbations in mitochondrial-related genes revealed by pooled imaging assay

Abstract Mutations in mitochondrial-related genes underlie numerous neurodegenerative diseases, yet the significance of most variants remains uncertain concerning disease phenotypes. Several thousand genes have been shown to regulate mitochondria in eukaryotic cells, but which of these genes are nec...

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Bibliographic Details
Main Authors: Colin Kremitzki, Jason Waligorski, Graham Bachman, Lina Mohammed Ali, John Bramley, Maria Vakaki, Vinay Chandrasekaran, Purva Patel, Dhruv Mathur, Paul Hime, Robi Mitra, Jeff Milbrandt, William Buchser
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Imaging
Online Access:https://doi.org/10.1038/s44303-025-00097-9
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