Preparation and Evaluation of an Oral Administration System of Albendazole-Metal-Organic Framework Based on Dual Response to pH and Enzymes

Preparation and Evaluation of an Oral Administration System of Albendazole-Metal-Organic Framework Based on Dual Response to pH and Enzymes

<b>Objective:</b> This study aims to develop a metal–organic framework (ABZ-MOFs)-based oral drug delivery system for albendazole (ABZ) to enhance its dissolution rate and oral bioavailability. <b>Methods:</b> ABZ@MOF-802, ABZ@UiO-66-NH<sub>2</sub>, and ABZ@MIL-12...

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Bibliographic Details
Main Authors: Weiqi Liu, Zhimei Guo, Yong Zhang, Yufei Guo, Ting Wang, Dahuan Liu, Chunhui Hu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
albendazole
metal–organic framework
pH- and enzyme-responsive release
transmembrane transport
bioavailability
Online Access:https://www.mdpi.com/1424-8247/18/6/819
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