Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer

Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer

Abstract Background Inter- and intra-tumor heterogeneity is considered a significant factor contributing to the development of endocrine resistance in breast cancer. Recent advances in single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) allow us to explore inter- and...

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Main Authors: Kun Fang, Aigbe G. Ohihoin, Tianxiang Liu, Lavanya Choppavarapu, Bakhtiyor Nosirov, Qianben Wang, Xue-Zhong Yu, Sailaja Kamaraju, Gustavo Leone, Victor X. Jin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Genome Medicine
Subjects:
Single-cell analysis
Epigenetic-regulated cancer cell states
Breast tumor heterogeneity
Online Access:https://doi.org/10.1186/s13073-024-01407-3
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https://doi.org/10.1186/s13073-024-01407-3

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