Neutrophil membrane-coated circular RNA nanoparticles for targeted immunotherapy in HER2-positive breast cancer brain metastasis

Neutrophil membrane-coated circular RNA nanoparticles for targeted immunotherapy in HER2-positive breast cancer brain metastasis

Abstract Breast cancer is the most prevalent malignancy worldwide, with approximately 50% of HER2-positive advanced breast cancer patients eventually developing brain metastases, significantly reducing survival. Current HER2-targeted therapies, such as trastuzumab, exhibit limited efficacy in patien...

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Bibliographic Details
Main Authors: Yunpeng Liu, Wei He, Xiaoju Li, Xiyan Lu, Chihua Wu, Yuan Gao, Dong Fan, Chao Dong, Huadong Zhao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
HER2-positive breast cancer
Brain metastases
Circular RNA
Immunotherapy
Blood-brain barrier
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12964-025-02321-w
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https://doi.org/10.1186/s12964-025-02321-w

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