High Trop-2 expression in pulmonary sarcomatoid carcinoma reveals antibody–drug conjugate targeting Trop-2 is a promising therapeutic approach

High Trop-2 expression in pulmonary sarcomatoid carcinoma reveals antibody–drug conjugate targeting Trop-2 is a promising therapeutic approach

Abstract Background Several antibody–drug conjugates (ADC) targeting Trophoblast cell surface antigen 2 (Trop-2) have been developed, demonstrating significant therapeutic efficacy in triple-negative breast cancer and non-small cell lung cancer. However, the current expression of Trop-2 in pulmonary...

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Main Authors: Xiaoying Qian, Chuanhong Luo, Chen Fang, Yongbin Wu, Weiwei Hong, Biao Yu, Guizhen Qin, Yan Yin, Xinyuan Yao, Xin Ye, Bingbiao Zhou, Chengsi Shu, Dengying Chen, Zhaoqing Li, Shanshan Wang, Yong Wang, Yong Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Pulmonary sarcomatoid carcinoma
Surgical
Trophoblast surface antigen 2
Intratumor heterogeneity
Antibody–drug conjugate
Online Access:https://doi.org/10.1186/s12967-025-06888-3
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https://doi.org/10.1186/s12967-025-06888-3

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