Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients

BackgroundPrevious studies have reported a reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (rs 776746). However, information regarding Colombian liver transplantation patients is scarce. This study aimed to investigate the influence of CYP3A5 polymorphism on t...

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Bibliographic Details
Main Authors: Erica Fernanda Lindarte, Gonzalo De Jesus Vasquez, Luis Guillermo Toro Rendón, Andrés Felipe Zuluaga Salazar, Jefferson Antonio Buendia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
CYP3A5 polymorphisms
liver transplant
Colombia
pharmacogenenomics and personalised medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1505490/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1505490/full

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