AMPGen: an evolutionary information-reserved and diffusion-driven generative model for de novo design of antimicrobial peptides

AMPGen: an evolutionary information-reserved and diffusion-driven generative model for de novo design of antimicrobial peptides

Abstract The rapid advancement of artificial intelligence (AI) has enabled de novo design of functional proteins, circumventing the reliance on natural templates or sequencing databases. However, current protein design models are ineffective in generating proteins without stable structures, such as...

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Main Authors: Shuwen Jin, Zihan Zeng, Xiyan Xiong, Baicheng Huang, Li Tang, Hongsheng Wang, Xiao Ma, Xiaochun Tang, Guoqing Shao, Xingxu Huang, Feng Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08282-7
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https://doi.org/10.1038/s42003-025-08282-7

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