Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling

Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling

Abstract Background & aims Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness. SEMAs are overexpressed in various cancers but their expression and role in the crosstalk between...

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Bibliographic Details
Main Authors: Liankang Sun, Huanhuan Wang, Hanqi Li, Ruida Yang, Xuyuan Dong, Danfeng Dong, Yangwei Fan, Enxiao Li, Hao Wang, Yinying Wu, Yu Shi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biology Direct
Subjects:
Gallbladder cancer
Matrix stiffness
Gallbladder fibroblasts
Semaphorin 7A
p300
EMT
Online Access:https://doi.org/10.1186/s13062-025-00683-2
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https://doi.org/10.1186/s13062-025-00683-2

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