Unveiling mismatch of RTS S AS01 and R21 Matrix M malaria vaccines haplotype among Ethiopian Plasmodium falciparum clinical isolates

Unveiling mismatch of RTS S AS01 and R21 Matrix M malaria vaccines haplotype among Ethiopian Plasmodium falciparum clinical isolates

Abstract Malaria vaccines, RTS, S/AS01 and R21/Matrix which are based on the Plasmodium falciparum circumsporozoite protein (Pfcsp) have been approved by WHO for broad use in children in Africa. However, the extensive genetic diversity of Pfcsp limited its effectiveness, as vaccine efficacy reduced...

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Bibliographic Details
Main Authors: Aynalem Mandefro, Alebachew Messele Kebede, Mitchel Katsvanga, Fatoumatta Cham, Eniyou Oriero, Alfred Amambua-Ngwa, Lemu Golassa
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Vaccines
Circumsporozoite protein
Genetic diversity
Plasmodium falciparum
Online Access:https://doi.org/10.1038/s41598-025-00140-0
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https://doi.org/10.1038/s41598-025-00140-0

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